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Increased frequency of immunogenic variants obtained by repeated mutagen treatment of mouse mastocytoma P815

✍ Scribed by Boon, Thierry; Marchand, Marie; Caspar, Philippe

Book ID
122824058
Publisher
Elsevier Science
Year
1983
Weight
996 KB
Volume
19
Category
Article
ISSN
0277-5379

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## Abstract After mutagenesis of mouse mastocytoma P815, it is possible to obtain variant (tum^βˆ’^) clones that are almost always rejected by syngeneic DBA/2 mice. Most tum^βˆ’^ clones express new variant‐specific antigens that can be detected by cytolytic T cells (CTL). Occasionally, mice injected wi