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Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. VII. Dominant expression of variant antigens in somatic cell hybrids

✍ Scribed by Janet L. Maryanski; Josiane Szpirer; Claude Szpirer; Thierry Boon

Book ID
112558893
Publisher
Springer
Year
1983
Tongue
English
Weight
645 KB
Volume
9
Category
Article
ISSN
1572-9931

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## Abstract After mutagenesis of mouse mastocytoma P815, it is possible to obtain variant (tum^βˆ’^) clones that are almost always rejected by syngeneic DBA/2 mice. Most tum^βˆ’^ clones express new variant‐specific antigens that can be detected by cytolytic T cells (CTL). Occasionally, mice injected wi