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Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. III. Clonal analysis of the syngeneic cytolytic T lymphocyte response

✍ Scribed by Janet L. Maryanski; Jacques Van Snick; Jean-Charles Cerottini; Thierry Boon

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 666 KB
Volume: 12
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830120508

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## Abstract After mutagenesis of mouse mastocytoma P815, it is possible to obtain variant (tum^−^) clones that are almost always rejected by syngeneic DBA/2 mice. Most tum^−^ clones express new variant‐specific antigens that can be detected by cytolytic T cells (CTL). Occasionally, mice injected wi