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Incorporation of 2-C-Methyl-d-erythritol, a Putative Isoprenoid Precursor in the Mevalonate-Independent Pathway, into Ubiquinone and Menaquinone of Escherichia coli

✍ Scribed by Tore Duvold; Patrizia Calí; Jean-Michel Bravo; Michel Rohmer

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
802 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Incorporationofdeutenum labelled2-C-metbyl-D-erytbritOl into isoprenoidside-chains of ubiquinoneandmenaquinonefromEscherichiocoli.stronglysupports theproposedintermediaterole of this branchedsugar derivativein the mevalonateindependentpathwayfor isoprenoidbiosynthesis via glycemfdehyde 3-phosphate~d Pmvak. @ 1997publishedby Elsevier ScienceLtd.

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Isoprenoid biosynthesis via the methylerythritol phosphate pathway: accumulation of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate in a gcpE deficient mutant of Escherichia coli
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In the bacterium Escherichia coli, gcpE is an essential gene in the methylerythritol phosphate pathway for isoprenoid biosynthesis. Incubation of [1-3 H]methylerythritol with an E. coli mutant defective in the gcpE gene resulted in the accumulation of [1-3 H]methylerythritol 2,4-cyclodiphosphate. Th