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Chemical Synthesis of Enantiopure 2-C-Methyl-d-Erythritol 4-Phosphate, the Key Intermediate in the Mevalonate-Independent Pathway for Isoprenoid Biosynthesis

✍ Scribed by Jean-François Hoeffler; C Pale-Grosdemange; Michel Rohmer

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
117 KB
Volume
56
Category
Article
ISSN
0040-4020

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✦ Synopsis

Optically pure 2-C-methyl-d-erythritol 4-phosphate, a key intermediate in the mevalonate-independent route for isoprenoid biosynthesis, is conveniently synthesized from 1,2-O-isopropylidene-a-d-xylofuranose, including the possibility of radiolabeling of this substrate.

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