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In vivo transformation of arachidonic acid into 12-hydroxy-5,8,10,14-eicosatetraenoic acid by human nasal mucosa

✍ Scribed by Isabel Ramis; Joan Roselló-Catafau; Emilio Gelpí


Book ID
103804354
Publisher
Elsevier Science
Year
1992
Weight
309 KB
Volume
575
Category
Article
ISSN
0378-4347

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12-Hydroxy-5Z, 8Z, 10E, 14Z, eicosatetra
✍ Shoko Ueki; Junichi Takagi; Yuichi Kobayashi; Fumie Sato; Yuji Saito 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB

We report here that the 12-lipoxygenase metabolite of arachidonic acid, 12hydroxy-5Z, 8Z, 10E, 14Z, eicosatetraenoic acid (12-HETE), stimulates cAMP production in human fibroblasts among various cultured cell lines tested. Although 12-HETE seemed to stimulate the phospholipase C (PLC)-protein kinase