12-Hydroxy-5Z, 8Z, 10E, 14Z, eicosatetra
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Shoko Ueki; Junichi Takagi; Yuichi Kobayashi; Fumie Sato; Yuji Saito
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Article
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1999
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John Wiley and Sons
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English
โ 150 KB
We report here that the 12-lipoxygenase metabolite of arachidonic acid, 12hydroxy-5Z, 8Z, 10E, 14Z, eicosatetraenoic acid (12-HETE), stimulates cAMP production in human fibroblasts among various cultured cell lines tested. Although 12-HETE seemed to stimulate the phospholipase C (PLC)-protein kinase