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Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 5,12-dihydroxyeicosatetraenoic acid (leukotriene B4) in psoriasis and normal human skin

โœ Scribed by P. M. Dowd; A. Kobza Black; P. W. Woollard; M. W. Greaves


Book ID
104763769
Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
741 KB
Volume
279
Category
Article
ISSN
0340-3696

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12-Hydroxy-5Z, 8Z, 10E, 14Z, eicosatetra
โœ Shoko Ueki; Junichi Takagi; Yuichi Kobayashi; Fumie Sato; Yuji Saito ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 150 KB

We report here that the 12-lipoxygenase metabolite of arachidonic acid, 12hydroxy-5Z, 8Z, 10E, 14Z, eicosatetraenoic acid (12-HETE), stimulates cAMP production in human fibroblasts among various cultured cell lines tested. Although 12-HETE seemed to stimulate the phospholipase C (PLC)-protein kinase