In vivo MR imaging and spectroscopy using hyperpolarized 129Xe

✍ Scribed by Mark E. Wagshul; Terry M. Button; Haifang F. Li; Zhengrong Liang; Charles S. Springer; Kai Zhong; Arnold Wishnia

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 1019 KB
• Volume: 36
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910360203

✦ Synopsis

Abstract

Hyperpolarized ^129^Xe has been used to obtain gas phase images of mouse lung in vivo, showing distinct ventilation variation as a function of the breathing cycle. Spectra of ^129^Xe in the thorax show complex structure in both the gas phase (−4 to 3 ppm) and tissue‐dissolved (190‐205 ppm) regions. The alveolar gas peak shows correlated intensity and frequency oscillations, both attributable to changes in lung volume during breathing. The two major dissolved peaks near 195‐200 ppm are attributed to lung parenchyma and to blood; they reach maximum intensity in 5‐10 s and decay with an apparent T~1~ of 30 s. Another peak at 190 ppm takes 20‐30 s to reach maximum; this must represent other well‐vascularized tissue (e.g., heart and other muscles) in the thorax. The maximum integrated area of the tissue components reaches 30–80% of the maximum alveolar gas area, indicating that imaging at tissue frequencies can be achieved.