Xenon-129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion

✍ Scribed by Guillaume Duhamel; Philippe Choquet; Emmanuelle Grillon; Laurent Lamalle; Jean-Louis Leviel; Anne Ziegler; André Constantinesco

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 156 KB
• Volume: 46
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1180

✦ Synopsis

Abstract

Hyperpolarized ^129^Xe dissolved in a lipid emulsion constitutes an NMR tracer that can be injected into the blood stream, enabling blood‐flow measurement and perfusion imaging. A small volume (0.15 ml) of this tracer was injected in 1.5 s in rat carotid and ^129^Xe MR spectra and images were acquired at 2.35 T to evaluate the potential of this approach for cerebral studies. Xenon spectra consistently showed two resonances, at 194.5 ppm and 199.0 ppm relative to the gas peak. The signal‐to‐noise ratio (SNR) obtained for the two peaks was sufficient (ranging from 12 to 90) to follow their time courses. 2D transverse‐projection xenon images were obtained with an in‐plane resolution of 900 μm per pixel (SNR range 8–15). Histological analysis revealed no brain damage except in two rats that had received three injections. Magn Reson Med 46:208–212, 2001. © 2001 Wiley‐Liss, Inc.