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In vivo MRI using real-time production of hyperpolarized 129Xe

✍ Scribed by Bastiaan Driehuys; Jim Pollaro; Gary P. Cofer

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
552 KB
Volume
60
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

MR imaging of hyperpolarized (HP) nuclei is challenging because they are typically delivered in a single dose of nonrenewable magnetization, from which the entire image must be derived. This problem can be overcome with HP ^129^Xe, which can be produced sufficiently rapidly to deliver in dilute form (1%) continuously and on‐demand. We demonstrate a real‐time in vivo delivery of HP ^129^Xe mixture to rats, a capability we now routinely use for setting frequency, transmitter gain, shimming, testing pulse sequences, scout imaging, and spectroscopy. Compared to images acquired using conventional fully concentrated ^129^Xe, real‐time ^129^Xe images have 26‐fold less signal, but clearly depict ventilation abnormalities. Real‐time ^129^Xe MRI could be useful for time‐course studies involving acute injury or response to treatment. Ultimately, real‐time ^129^Xe MRI could be done with more highly concentrated ^129^Xe, which could increase the signal‐to‐noise ratio by 100 relative to these results to enable a new class of gas imaging applications. Magn Reson Med 60:14–20, 2008. © 2008 Wiley‐Liss, Inc.

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