## Abstract Dynamic nuclear polarization can be used to increase the sensitivity of solution state ^13^C magnetic resonance spectroscopy by four orders of magnitude. We show here that [1β^13^C]glutamate can be polarized to 28%, representing a 35,000βfold increase in its sensitivity to detection at
Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy
β Scribed by Kevin M. Brindle; Sarah E. Bohndiek; Ferdia A. Gallagher; Mikko I. Kettunen
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 800 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We show here that hyperpolarized [1β^13^C]pyruvate can be used to detect treatment response in a glioma tumor model; a tumor type where detection of response with ^18^fluoroβ2βdeoxyglucose, using positron emission tomography, is limited by the high background signals from normal brain t
## Abstract The ability to accelerate the spatial encoding process during a chemical shift imaging (CSI) scan of hyperpolarized compounds is demonstrated through parallel imaging. A hardware setup designed to simultaneously acquire ^13^C data from multiple receivers is presented here. A system cons
## Abstract Carboxypeptidase G2 (CPG2) is a bacterial enzyme that is currently employed in a range of targeted cancer chemotherapy strategies such as geneβdirected enzyme prodrug therapy (GDEPT). Employing dynamic nuclear polarization (DNP) and natural abundance ^13^C magnetic resonance spectroscop
## Abstract [1β^13^C]Pyruvate is a readily polarizable substrate that has been the subject of numerous magnetic resonance spectroscopy (MRS) studies of in vivo metabolism. In this work ^13^CβMRS of hyperpolarized [1β^13^C]pyruvate was used to interrogate a metabolic pathway involved in neither aero