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In vivo hyperpolarized 129Xe NMR spectroscopy in tumors

✍ Scribed by Jan Wolber; Dominick J.O. McIntyre; Loreta M. Rodrigues; Paul Carnochan; John R. Griffiths; Martin O. Leach; Angelo Bifone

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
586 KB
Volume
46
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The first in vivo hyperpolarized ^129^Xe NMR study in experimental tumors is presented. Hyperpolarized ^129^Xe was dissolved in solutions, and was injected intratumorally in GH‐3 prolactinomas in rats and RIF‐1 fibrosarcomas in mice. The ^129^Xe NMR spectra and apparent spin‐lattice relaxation times in the two tumor types present characteristic differences. These differences are discussed in terms of xenon exchange between the carrier medium and the tissue compartments. Magn Reson Med 46:586–591, 2001. Β© 2001 Wiley‐Liss, Inc.

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