Dynamic NMR spectroscopy of hyperpolarized 129Xe in human brain analyzed by an uptake model
✍ Scribed by Wolfgang Kilian; Frank Seifert; Herbert Rinneberg
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 307 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Hyperpolarized ^129^Xe (HpXe) NMR not only holds promise for functional lung imaging, but for measurements of tissue perfusion as well. To investigate human brain perfusion, several time‐series of ^129^Xe MR spectra were recorded from one healthy volunteer after HpXe inhalation. The time‐dependent amplitudes of the MR spectra were analyzed by using a compartment model for xenon uptake modified to account for the loss of ^129^Xe polarization due to RF‐excitation and for the breathhold technique used in the experiments. This analysis suggests that the resonances detected at 196.5 ± 1 ppm and 193 ± 1 ppm originate from HpXe dissolved in gray and white matter, respectively, and that T~1~ relaxation times of HpXe are different in gray and white matter (T~1g~ > T~1w~). Magn Reson Med 51:843–847, 2004. © 2004 Wiley‐Liss, Inc.