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In vitro model for the activation of CD4 and CD8 T cell receptors

โœ Scribed by Borros M. Arneth

Book ID
116532263
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
325 KB
Volume
70
Category
Article
ISSN
0198-8859

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta