CD4/CD8 lineage commitment in T cell receptor transgenic mice: evidence for precommitment of CD4+ CD8+ thymocytes
β Scribed by Tessa Crompton; Hanspeter Hefti; Rosemary K. Lees; Hanspeter Pircher; H.Robson MacDonald
- Book ID
- 115647764
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 500 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1044-5323
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π SIMILAR VOLUMES
MHC specificity in positive selection is a major determinant in the CD4/CD8 T cell lineage decision. Previous studies support the view that quantitative differences in T cell receptor (TCR) signaling in immature CD4 + CD8 + double positive thymocytes leads to an instructive bias in CD4/CD8 T cell li
A differentiation pathway from CD4+CD8+ cells to CD4+CD8- or CD4-CD8+ cells was investigated in athymic nude mice. Using fluorescence-activated cell sorter, CD4+CD8+ cells were sorted out from AKR thymocytes (H-2k, Thy-1.1) stained with two monoclonal antibodies against CD4 and CD8 (anti-L3T4 and an