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Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

✍ Scribed by Gabriela Hernández-Hoyos; Sue J Sohn; Ellen V Rothenberg; José Alberola-Ila

Book ID
117722612
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
230 KB
Volume
12
Category
Article
ISSN
1074-7613

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MHC specificity in positive selection is a major determinant in the CD4/CD8 T cell lineage decision. Previous studies support the view that quantitative differences in T cell receptor (TCR) signaling in immature CD4 + CD8 + double positive thymocytes leads to an instructive bias in CD4/CD8 T cell li