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Functional Analysis of Cd2, cd4, and cd8 in t-Cell Activation

✍ Scribed by BARBARA E. BIERER; JULIA L. GREENSTEIN; BARRY SLECKMAN; SHELDON RATNOFSKY; ANDY PETERSON; BRIAN SEED; STEVEN J. BURAKOFF

Book ID
119861884
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
401 KB
Volume
532
Category
Article
ISSN
0890-6564

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta