CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta
β¦ LIBER β¦
The role of CD4 T cell help for CD8 CTL activation
β Scribed by Sheng Zhang; Hongjun Zhang; Jiandong Zhao
- Book ID
- 116298596
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 156 KB
- Volume
- 384
- Category
- Article
- ISSN
- 0006-291X
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## Abstract CD4^+^ T cell help during the priming of CD8^+^ T lymphocytes imprints the capacity for optimal secondary expansion upon reβencounter with antigen. Helped memory CD8^+^ T cells rapidly expand in response to a secondary antigen exposure, even in the absence of T cell help and, are most e
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