Towards a cellular definition of CD8+ T-cell memory: the role of CD4+ T-cell help in CD8+ T-cell responses
β Scribed by Benedita Rocha; Corinne Tanchot
- Book ID
- 108099460
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 124 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0952-7915
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## Abstract CD4^+^ T cell help during the priming of CD8^+^ T lymphocytes imprints the capacity for optimal secondary expansion upon reβencounter with antigen. Helped memory CD8^+^ T cells rapidly expand in response to a secondary antigen exposure, even in the absence of T cell help and, are most e
CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta