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In situ hybridization ascertains the presence of a translocation t(6;11) in an acute monocytic leukemia

✍ Scribed by Josette Derré; Dorra Cherif; Maryvonne Le Coniat; Cécile Julier; Roland Berger

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
272 KB
Volume
2
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

In situ hybridization was performed in a case of acute monoblastic leukemia (FAB type M5b) with a rearrangement of the long arm of chromosome 11. Cytogenetic analysis after R‐ and G‐banding showed an apparent deletion of 11q with a breakpoint at 11q23, and a translocation t(6;11) was suspected in certain metaphases. In situ hybridization with a biotinylated cosmid probe hybridizing at 11q25 confirmed the translocation t(6;11)(q27;q23). Use of nonradioactive in situ hybridization techniques for more precise characterization of chromosomal rearrangements in malignant cells is emphasized.

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