Third case of acute monocytic leukemia (M5) occurring in an HIV-Seropositive man: A case report

✍ Scribed by Regis T. Costello; Danièle Sainty; Laurence Heuberger; Jean-Albert Gastaut; Reda Bouabdallah

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 268 KB
• Volume: 49
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.2830490419

✦ Synopsis

Letters and Correspondence

changes in renal function. Proteinuria was reversible after withdrawal of the drug and was reproducible at reexposure. The extent of proteinuria was dose dependent. Renal biopsy revealed a (possibly pre-existing) minimal change glomerulonephritis. Uncovering of an underlying autoimmune defect by IFN seems an unlikely pathoetiologic mechanism, causing the observed renal functional impairment, since autoantibodies (ANA, autoantibodies against double-stranded DNA, RF, and ASL titer as well as CRP) were negative. Hyperuricemia as a causative agent was excluded, since serum uric acid levels were normal throughout the treatment period.

We conclude that IFN exhibits in rare instances a severe renal toxicity that may range from isolated proteinuria (as in our patient) to acute anuric renal failure [2]. Close monitoring of renal function during IFN therapy is warranted.

REFERENCES

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