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A new case of translocation t(6;11)(q21;q23) in a therapy-related acute myeloid leukemia resulting in an MLL–AF6q21 fusion

✍ Scribed by Olivier A. Bernard; Josette Hillion; Maryvonne Le Coniat; Roland Berger

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
88 KB
Volume
22
Category
Article
ISSN
1045-2257

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✦ Synopsis

A new case of translocation t(6;11)(q21;q23) in a patient with therapy-related acute myeloblastic leukemia is reported. The translocation results in fusion of the MLL and AF6q21 genes. The breakpoint with AF6q21 is located within the sequences encoding the AF6q21 fork head motif. The similar location of the localization of the chromosome 6 breakpoints in the present case and in the first case reported suggests their nonrandom localization. In addition, treatment for Hodgkin's disease prior to leukemia in both t(6;11)(q21;q23) cases suggests an association of this translocation with therapy-related leukemias, as reported for the recently described t(11;16)(q23;p13.3).

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