## Abstract We previously isolated an acyclovir (ACV)โresistant herpes simplex virus type 1 (HSVโ1), strain TAR, from a child with WiskottโAldrich syndrome. An acyclovirโsensitive HSVโ1, strain TAS, had been isolated from the same patient before the isolation of HSVโ1 TAR. The TK protein of ACVโsen
โฆ LIBER โฆ
Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity
โ Scribed by Sonia Burrel; Pascale Bonnafous; Petr Hubacek; Henri Agut; David Boutolleau
- Book ID
- 119190622
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 284 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0166-3542
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## Abstract We investigated some of the biological and biochemical characteristics of a neurovasive, retinovirulent herpes simplex virus type 2 strain SL (HSVโ2[SL]) and compared them with those of a neurovirulent, nonretinovirulent HSVโ2(186). HSVโ2(SL) was shown to spread rapidly and produce larg