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Cytopathogenicity, drug susceptibility, and thymidine kinase activity of a retinovirulent herpes simplex virus type 2

✍ Scribed by M. P. Langford; Dr. J. M. Colacino; R. Kaiwar; S. B. Mahjoub; J. P. Ganley

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
602 KB
Volume
31
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

We investigated some of the biological and biochemical characteristics of a neurovasive, retinovirulent herpes simplex virus type 2 strain SL (HSV‐2[SL]) and compared them with those of a neurovirulent, nonretinovirulent HSV‐2(186). HSV‐2(SL) was shown to spread rapidly and produce large syncytium in vitro. HSV‐2(SL) and HSV‐2(186) were equally susceptible to acyclovir (ACV) and thymine arabinoside (Ara‐T). However, HSV‐2(SL) was fourfold and 44‐fold more susceptible than HSV‐2(186) to iododeoxyuridine (IUdR) and bromovinyldeoxyuridene (BVDU), respectively. In addition, cytosolic TK from HSV‐2(SL)‐infected cells phosphorylated 4, 20, and 23,000 times more IUdR, iododeoxycytidine (IdCyD), and Ara‐T than the TK of HSV‐2(186), respectively. Further, HSV‐2(186) replication was inhibited by Ara‐T. These studies indicate that the retinovirulent HSV‐2(SL) has a syn phenotype and a TK with broad substrate activity.

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