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Immunofluorescent study of the group-specific antigen of murine leukemia viruses

✍ Scribed by O. M. Lejneva; G. I. Abelev

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
624 KB
Volume
6
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

In the present work a method is described for obtaining monospecific antibodies to the group‐specific antigen of the murine leukemia viruses (MuLV‐gs). This antigen is demonstrated in normal and malignant tissues by the indirect immunofluorescence technique. The MuLV‐gs was demonstrated in Rauscher leukemic spleen cells of BALB/c mice and in normal spleen cells of high‐leukemic AKR and some low‐leukemic mice. The MuLV‐gs was shown in cells of methylcholanthrene‐induced sarcomas and in cells of tumors induced with polyoma virus. The MuLV‐gs was not revealed in III Af mouse sarcoma induced by Rous virus.

The specificity of the reaction was confirmed by the specific inhibition of the fluorescence after neutralization of the antibodies by the partly‐purified MuLV‐gs. The results obtained with the immunofluorescence technique coincided with those of agar precipitation analysis.

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