Prevalence of the group-specific (gs) antigen and infectious virus expressions of the murine C-type RNA viruses during the life span of BALB/cCr mice

✍ Scribed by Robert L. Peters; Janet W. Hartley; Gerard J. Spahn; Louise S. Rabstein; Carrie E. Whitmire; Horace C. Turner; Robert J. Huebner

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: French
• Weight: 495 KB
• Volume: 10
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910100208

✦ Synopsis

Abstract

The prevalence of C‐type RNA tumor‐virus gs antigen and infectious virion expression was determined at various ages throughout the life span of the BALB/cCr mouse. The incidence of gs antigen was low (2.5%) prior to 6 months of age, but increased progressively to 71% in mice over 24 months of age. The incidence of infectious virus isolated in mouse embryo cell culture was low (10%) prior to 6 months of age, but rose rapidly after 6 months of age and remained relatively stable (varying from 46% to 62%) throughout the remainder of life. Eighteen of nineteen isolations made prior to 1 year of age were made on NIH Swiss mouse embryo cells as opposed to BALB/c mouse embryo cells (1/19). In older mice, isolations on BALB/c cells increased, but only after 24 months of age were isolation rates higher than on NIH Swiss cells. Isolations from the spleens of mice with malignancies were somewhat more frequent than from spleens of mice which were normal or had histologically benign tumors.