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Identification of transferrin receptor 1 as a hepatitis C virus entry factor

✍ Scribed by Martin, D. N.; Uprichard, S. L.

Book ID
121373587
Publisher
National Academy of Sciences
Year
2013
Tongue
English
Weight
539 KB
Volume
110
Category
Article
ISSN
0027-8424

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Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the tr