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Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

✍ Scribed by Ploss, Alexander; Evans, Matthew J.; Gaysinskaya, Valeriya A.; Panis, Maryline; You, Hana; de Jong, Ype P.; Rice, Charles M.


Book ID
118675870
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
406 KB
Volume
457
Category
Article
ISSN
0028-0836

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Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide. Scavenger receptor class B type I (SR-BI) has been shown to bind HCV envelope glycoprotein E2, participate in entry of HCV pseudotype particles, and modulate HCV infection. However, the functional role of SR-BI for productive H