Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication
✍ Scribed by Frédéric H. Vaillancourt; Louise Pilote; Mireille Cartier; Julie Lippens; Michel Liuzzi; Richard C. Bethell; Michael G. Cordingley; George Kukolj
- Book ID
- 113947791
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 703 KB
- Volume
- 387
- Category
- Article
- ISSN
- 0042-6822
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Hepatitis C virus (HCV) replication is highly dependent on host cell factors. Identification of these host factors not only facilitates understanding of the biology of HCV infection but also enables the discovery of novel targets for anti-HCV therapy. To identify host genes important for HCV RNA rep
## Abstract Hepatitis C virus (HCV) is the major causative agent of blood‐borne hepatitis. The majority of HCV‐infected individuals develop chronic hepatitis, which eventually progresses to liver cirrhosis, and hepatocellular carcinoma. Although the precise mechanisms of entry, replication, assembl
Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the tr