✦ LIBER ✦
Triglyceride synthesis and hepatitis C virus production: Identification of a novel host factor as antiviral target
✍ Scribed by Catherine Schuster; Mathieu Lefèvre; Thomas F. Baumert
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 309 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown of DGAT1 severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy.