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Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry

✍ Scribed by Evans, Matthew J.; von Hahn, Thomas; Tscherne, Donna M.; Syder, Andrew J.; Panis, Maryline; Wölk, Benno; Hatziioannou, Theodora; McKeating, Jane A.; Bieniasz, Paul D.; Rice, Charles M.

Book ID
109896571
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
371 KB
Volume
446
Category
Article
ISSN
0028-0836

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Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide. Scavenger receptor class B type I (SR-BI) has been shown to bind HCV envelope glycoprotein E2, participate in entry of HCV pseudotype particles, and modulate HCV infection. However, the functional role of SR-BI for productive H