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Identification of susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a two stage genome scan of affected sib-pairs

✍ Scribed by N.J. Prescott; M.M. Lees; R.M. Winter; S. Malcolm


Book ID
106137235
Publisher
Springer
Year
2000
Tongue
English
Weight
47 KB
Volume
106
Category
Article
ISSN
0340-6717

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Genome scan for loci involved in nonsynd
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## Abstract In order to identify genes or regions involved in nonsyndromic cleft lip with or without cleft palate (CL/P) in families from India, we analyzed 38 multiplex families (DNA from 272 individuals, 82 affected with CL/P, 190 unaffected) for 285 genome‐wide markers (average spacing 12.6 cM),

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## Abstract Non‐syndromic cleft lip with/without cleft palate (CL/P) is a common, usually non‐fatal birth defect of complex etiology. Several segregation analyses have demonstrated that genetic factors are important in the pathogenesis of CL/P, most likely through the interaction of several genes o