Identification of susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a two stage genome scan of affected sib-pairs
β Scribed by N.J. Prescott; M.M. Lees; R.M. Winter; S. Malcolm
- Book ID
- 106137235
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 47 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0340-6717
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## Abstract In order to identify genes or regions involved in nonsyndromic cleft lip with or without cleft palate (CL/P) in families from India, we analyzed 38 multiplex families (DNA from 272 individuals, 82 affected with CL/P, 190 unaffected) for 285 genomeβwide markers (average spacing 12.6 cM),
## Abstract Nonβsyndromic cleft lip with/without cleft palate (CL/P) is a common, usually nonβfatal birth defect of complex etiology. Several segregation analyses have demonstrated that genetic factors are important in the pathogenesis of CL/P, most likely through the interaction of several genes o