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Genome-wide and Interaction Linkage Scan for Nonsyndromic Cleft Lip with or without Cleft Palate in Two Multiplex Families in Shenyang, China

✍ Scribed by Yun WANG; Xin LI; Wen-Li ZHU; Jin-Zhen GUO; Xiao-Ming SONG; Shu-Qin LI; Yong LI


Book ID
117596769
Publisher
Chinese Electronic Periodical Services
Year
2010
Tongue
English
Weight
510 KB
Volume
23
Category
Article
ISSN
0895-3988

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Genome scan for loci involved in nonsynd
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## Abstract In order to identify genes or regions involved in nonsyndromic cleft lip with or without cleft palate (CL/P) in families from India, we analyzed 38 multiplex families (DNA from 272 individuals, 82 affected with CL/P, 190 unaffected) for 285 genome‐wide markers (average spacing 12.6 cM),

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## Abstract Non‐syndromic cleft lip with/without cleft palate (CL/P) is a common, usually non‐fatal birth defect of complex etiology. Several segregation analyses have demonstrated that genetic factors are important in the pathogenesis of CL/P, most likely through the interaction of several genes o

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## Abstract Cleft lip with or without cleft palate (CL/P) is a common congenital anomaly, with birth prevalence ranging from 1/500 to 1/1,000. A number of genetic loci have shown positive linkage or association results in European Caucasian populations. The purpose of the current study was to asses

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The identification of several putative susceptibility loci for nonsyndromic cleft lip with or without cleft palate (CL f P) has sparked a renewed interest in the genetics of this condition. However, prior to undertaking linkage studies for complex traits such as CL f P it is desirable to have some u