## Abstract ## BACKGROUND Nonsyndromic cleft lip with or without cleft palate is a common birth defect. Although a number of susceptibility loci have been reported, replication has often been lacking. This is likely due, in part, to the heterogeneity of datasets and methodologies. Two independent
✦ LIBER ✦
Replication of novel susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 in Estonian and Lithuanian patients
✍ Scribed by Tiit Nikopensius; Laima Ambrozaitytė; Kerstin U. Ludwig; Stefanie Birnbaum; Triin Jagomägi; Mare Saag; Aušra Matulevičienė; Laura Linkevičienė; Stefan Herms; Michael Knapp; Per Hoffmann; Markus M. Nöthen; Vaidutis Kučinskas; Andres Metspalu; Elisabeth Mangold
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 71 KB
- Volume
- 149A
- Category
- Article
- ISSN
- 1552-4825
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## Abstract **INTRODUCTION:** Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all birth defects. NSCL/P has a multifactorial etiology that includes both genetic and environmental factors. The __IRF6__ gene and three further susceptibility loci at 8q24, 10q2