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Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

✍ Scribed by Mangold, Elisabeth; Ludwig, Kerstin U; Birnbaum, Stefanie; Baluardo, Carlotta; Ferrian, Melissa; Herms, Stefan; Reutter, Heiko; de Assis, Nilma Almeida; Chawa, Taofik Al; Mattheisen, Manuel


Book ID
109914552
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
246 KB
Volume
42
Category
Article
ISSN
1061-4036

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## Abstract In order to identify genes or regions involved in nonsyndromic cleft lip with or without cleft palate (CL/P) in families from India, we analyzed 38 multiplex families (DNA from 272 individuals, 82 affected with CL/P, 190 unaffected) for 285 genome‐wide markers (average spacing 12.6 cM),

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## Abstract Non‐syndromic cleft lip with/without cleft palate (CL/P) is a common, usually non‐fatal birth defect of complex etiology. Several segregation analyses have demonstrated that genetic factors are important in the pathogenesis of CL/P, most likely through the interaction of several genes o