Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
β Scribed by Mangold, Elisabeth; Ludwig, Kerstin U; Birnbaum, Stefanie; Baluardo, Carlotta; Ferrian, Melissa; Herms, Stefan; Reutter, Heiko; de Assis, Nilma Almeida; Chawa, Taofik Al; Mattheisen, Manuel
- Book ID
- 109914552
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 246 KB
- Volume
- 42
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng.506
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## Abstract In order to identify genes or regions involved in nonsyndromic cleft lip with or without cleft palate (CL/P) in families from India, we analyzed 38 multiplex families (DNA from 272 individuals, 82 affected with CL/P, 190 unaffected) for 285 genomeβwide markers (average spacing 12.6 cM),
## Abstract Nonβsyndromic cleft lip with/without cleft palate (CL/P) is a common, usually nonβfatal birth defect of complex etiology. Several segregation analyses have demonstrated that genetic factors are important in the pathogenesis of CL/P, most likely through the interaction of several genes o