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A Genome-Wide Association Study Identifies a Locus for Nonsyndromic Cleft Lip with or without Cleft Palate on 8q24

✍ Scribed by Struan F.A. Grant; Kai Wang; Haitao Zhang; Wendy Glaberson; Kiran Annaiah; Cecilia E. Kim; Jonathan P. Bradfield; Joseph T. Glessner; Kelly A. Thomas; Maria Garris; Edward C. Frackelton; F. George Otieno; Rosetta M. Chiavacci; Hyun-Duck Nah; Richard E. Kirschner; Hakon Hakonarson


Book ID
113745427
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
448 KB
Volume
155
Category
Article
ISSN
1097-6833

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An association between nonsyndromic cleft lip with or without cleft palate (CLΒ±P) and genetic variation at the transforming growth factor Ξ± (TGFA) locus was originally reported in 1989. Subsequent population-based studies of this association have provided conflicting results. The present analyses we