Lack of evidence for a significant association between nonsyndromic cleft lip with or without cleft palate and the retinoic acid receptor alpha gene in the Japanese population
โ Scribed by K. Kanno; Y. Suzuki; X. Yang; A. Yamada; Y. Aoki; S. Kure; Y. Matsubara
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 57 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1435-232X
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## Abstract ## Objectives/Hypothesis: Interferon regulatory factor 6 (__IRF6__), the gene that causes van der Woude syndrome (VWS), is a candidate gene for nonsyndromic cleft lip with or without cleft palate (NSCLP) because a number of studies have supported an association between NSCLP and single
## Abstract ## BACKGROUND Cleft lip with or without cleft palate (CL/P) is one of the most common craniofacial malformations, with a complex and multifactorial etiology. Because of the genetic heterogeneity of facial clefts, the aim of this study was to investigate the contribution of previously r