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Identification of fragmentation in matrix-assisted laser desorption mass spectrometry using a voltage labelling technique

✍ Scribed by Ian G. Hughes; Victor Morozov; Brian Merron; Jim Boyle; John Rainnie; Ian D. Williams; R. Jeremy H. Davies

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
138 KB
Volume
11
Category
Article
ISSN
0951-4198

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✦ Synopsis

A novel technique is presented for the study of post-source decay in matrix-assisted laser desorption time-of-flight mass spectrometry. By introducing a voltage labelling cell within the field-free region we have been able to distinguish between intact ions, fragmented ions and neutrals in a linear time-of-flight instrument. Results are presented for positive and negative ions of bovine insulin (MW 5733) which demonstrate the potential of the technique for investigating the effect of source conditions on post-source fragmentation.

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