✦ LIBER ✦

Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)

✍ Scribed by Graeme Semple; Vincent J. Santora; Jeffrey M. Smith; Jonathan A. Covel; Rena Hayashi; Charlemagne Gallardo; Jason B. Ibarra; Jeffrey A. Schultz; Douglas M. Park; Scott A. Estrada; Brian J. Hofilena; Brian M. Smith; Albert Ren; Marissa Suarez; John Frazer; Jeffrey E. Edwards; Ryan Hart; Erin K. Hauser; Jodie Lorea; Andrew J. Grottick

Book ID: 113496411
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 319 KB
Volume: 22
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2011.11.075

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Identification of B

ChemInform Abstract: Identification of Biaryl Sulfone Derivatives as Antagonists of the Histamine H3 Receptor: Discovery of (R)-1-(2-(4′- (3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).

✍ Graeme Semple; et al. et al. 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 19 KB

Discovery and Characterization of 6-{4-[

Discovery and Characterization of 6-{4-[3-( R )-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2 H -pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H 3 Receptor Inverse Agonist

✍ Hudkins, Robert L.; Raddatz, Rita; Tao, Ming; Mathiasen, Joanne R.; Aimone, Lisa 📂 Article 📅 2011 🏛 American Chemical Society 🌐 English ⚖ 1007 KB

Identification of an Orally Active Opioi

Identification of an Orally Active Opioid Receptor-like 1 (ORL1) Receptor Antagonist 4-{3-[(2 R )-2,3-Dihydroxypropyl]-2-oxo-2,3-dihydro-1 H -benzimidazol-1-yl}-1-[(1 S ,3 S ,4 R )-spiro[bicyclo[2.2.1]heptane-2,1′-cyclopropan]-3-ylmethyl]piperidine as Clinical Candidate

✍ Satoh, Atsushi; Sagara, Takeshi; Sakoh, Hiroki; Hashimoto, Masaya; Nakashima, Hi 📂 Article 📅 2009 🏛 American Chemical Society 🌐 English ⚖ 841 KB

Discovery of the First Potent and Select

Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2H-benzimidazol-2-one (J-113397)

✍ Kawamoto, Hiroshi; Ozaki, Satoshi; Itoh, Yoshiki; Miyaji, Mitsuru; Arai, Sachie; 📂 Article 📅 1999 🏛 American Chemical Society 🌐 English ⚖ 73 KB

The Discovery of N -((2 H -Tetrazol-5-yl

The Discovery of N -((2 H -Tetrazol-5-yl)methyl)-4-(( R )-1-((5 r ,8 R )-8-( tert -butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

✍ DeMong, Duane; Dai, Xing; Hwa, Joyce; Miller, Michael; Lin, Sue-Ing; Kang, Ling; 📂 Article 📅 2014 🏛 American Chemical Society 🌐 English ⚖ 529 KB

ChemInform Abstract: Discovery of the Fi

ChemInform Abstract: Discovery of the First Potent and Selective Small Molecule Opioid Receptor-Like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-4-piperidyl] -3-ethyl-1,3-diyhdro-2H-benzimidazol-2-one (J-113397).

✍ Hiroshi Kawamoto; Satoshi Ozaki; Yoshiki Itoh; Mitsuru Miyaji; Sachie Arai; Hiro 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views