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Hyperpolarized 129Xe T1 in oxygenated and deoxygenated blood

✍ Scribed by Mitchell S. Albert; Dilip Balamore; Daniel F. Kacher; Arvind K. Venkatesh; Ferenc A. Jolesz


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
183 KB
Volume
13
Category
Article
ISSN
0952-3480

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In previous experiments by the authors, in which hyperpolarized 129 Xe was dissolved in fresh blood samples, the T 1 was found to be strongly dependent on the oxygenation level, the values increasing with oxygenation: T 1 was about 4 s in deoxygenated samples and about 13 s in oxygenated samples. C.

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Optically enhanced NMR with 129 Xe and 3 He is emerging as a novel and promising technique for medical imaging of lungs and other tissues. Here it is shown that hyperpolarized 129 Xe NMR provides a powerful means of measuring blood oxygenation quantitatively and noninvasively. The interaction of xen

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## Abstract MR imaging of hyperpolarized (HP) nuclei is challenging because they are typically delivered in a single dose of nonrenewable magnetization, from which the entire image must be derived. This problem can be overcome with HP ^129^Xe, which can be produced sufficiently rapidly to deliver i