Hyperpolarized 129Xe NMR as a probe for blood oxygenation

✍ Scribed by Jan Wolber; Andrea Cherubini; Martin O. Leach; Angelo Bifone

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 167 KB
• Volume: 43
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/(sici)1522-2594(200004)43:4<491::aid-mrm1>3.0.co;2-6

✦ Synopsis

Optically enhanced NMR with 129 Xe and 3 He is emerging as a novel and promising technique for medical imaging of lungs and other tissues. Here it is shown that hyperpolarized 129 Xe NMR provides a powerful means of measuring blood oxygenation quantitatively and noninvasively. The interaction of xenon with hemoglobin is responsible for an oxygen-dependent NMR shift of 129 Xe in red blood cells, in sharp contrast to the current model of xenon-hemoglobin binding. This effect could be exploited in brain functional studies, and in the assessment of conditions and diseases affected by blood oxygenation. Magn