**The mixture of homologous nucleotide fragments** usually formed during carrierβoligonucleotide synthesis can be separated chromatographically so as to isolate the desired fragment, if the latter is protected at the 5β²βend with a hexadecyloxytrityl group (see __(2)__ in the previous communication).
Hydrogen Peroxide Oxidation of Phosphite Triesters in Oligonucleotide Syntheses
β Scribed by Cvetovich, Raymond J.
- Book ID
- 121229834
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 74 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1083-6160
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2-Methylsulfonylethoxy dichlorophosphine has been converted into the mono-N-morpholino derivative and applied for the preparation of 5'-D,N-protected d-nucleoside-3'-phosphoramidites. The latter intermediates could be used in the presence of 1-hydroxyben~otriazole for the formation of 3'-5'-phosphot
## Abstrad Based on the fact that the thalhmetnc oxldattons of hydrogen peroxide, oxalate and phosptute proceed selectively m the presence of Fe(II), chloride and bronude, titmnetrlc and spectrophotometrlc methods are described for the analysis of ternary mixtures of hydrogen peroxide, oxalate and
The oxidation of triphenylphosphine to the corresponding oxide in pyridine is faster in the presence ofFe m compounds, especially FeCI3. Even greater effects are seen for the oxidation oftrimethyl phosphite.