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Human restriction fragment length polymorphisms and cancer risk assessment

✍ Scribed by Theodore G. Krontiris; Nancy A. DiMartino; Mark Colb; H. David Mitcheson; David R. Parkinson

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 764 KB
Volume: 30
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240300405

No coin nor oath required. For personal study only.

✦ Synopsis

The polymorphic restriction fragments of the human Ha-rus locus, produced by the variable tandem repetition (VTR) of a short consensus sequence, fall into three classes based on allelic frequencies. Alleles of the "rare" class (individual frequencies <0.5%) have been detected only in white blood cell and tumor DNA of cancer patients. This phenomenon is independent of ethnic origin. No significant association of rare alleles with cancer patients has been demonstrated at an independent tandem repeat locus, VTR4.1. The results suggest that the Ha-rus restriction fragment length polymorphism is useful in cancer risk assessment.

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