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HLA-DR restriction-fragment-length polymorphisms in narcolepsy

✍ Scribed by Dr. J. D. Holloman; J. I. Bell; T. S. Kilduff; W. C. Dement; C. Guilleminault; H. O. McDevitt

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 595 KB
Volume: 18
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490180134

No coin nor oath required. For personal study only.

✦ Synopsis

Seventeen white patients from the Stanford Sleep Disorders Clinic complaining of excessive daytime somnolence (EDS) were selected for restriction-fragmentlength polymorphism (RF'LP) studies. Fourteen of the patients with clinically diagnosed narcolepsy were seropositive for DR2. RFLP analysis of these patients compared with a homozygous DR2-Dw2 cell line failed to reveal any polymorphism when digested with six restriction endonucleases and hybridized with three different cDNA probes. None of the three patients with central nervous system hypersomnia, a syndrome similar to narcolepsy, were DR2-positive. We conclude that any polymorphism of the DRP, DQa, or DQP genes of DR2 narcoleptics that might distinguish them from DR2 normals cannot be resolved through RFLP analysis.

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