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Restriction fragment length polymorphisms in the D7S1 region of human chromosome 7

✍ Scribed by B. Carritt

Publisher: Springer
Year: 1986
Tongue: English
Weight: 391 KB
Volume: 72
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00278824

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✦ Synopsis

A restriction fragment length polymorphism in the D7S1 region of chromosome 7 is detected by hybridizing the recombinant plasmid pA2H3 to HindIII- or HinfI-digested human DNA. Three HindIII and two HinfI alleles were detected, and it was found that all individuals carrying the variant HinfI allele also had the commoner of the two variant HindIII alleles. All variants seem to result from point mutation in restriction enzyme recognition sites. Restriction mapping of the D7S1 region revealed that the associated HindIII and HinfI alleles are defined by sites 300 base-pairs (bp) apart, and it is suggested that the close proximity of these sites is sufficient to account for the strong phenotype association observed.

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