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Restriction fragment length polymorphism in the 3′ flanking region of the rabbit β1-globin gene

✍ Scribed by Piero Masina; Andrea Rando; Sergio Cocozza

Publisher
Springer
Year
1984
Tongue
English
Weight
435 KB
Volume
22
Category
Article
ISSN
0006-2928

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✦ Synopsis

Southern blot analysis, a restriction fragment length polymorphism in the 3' flanking region of the rabbit 31-globin gene was detected. Two alleles, characterized by 9.7-and 12.4-kb BamH1 fragments and by 15.3-and 18.0-kb HindlII fragments, have been detected in a small population of White New Zealand rabbits. The long allele is the most frequent (about 70%). The simultaneous changes in the restriction patterns of the two endonucleases and the constant distance between BamHI and HindlII sites in short and long fragments suggest the possibility that the two alleles arise from a rearrangement phenomenon involving a DNA segment 2.7 kb long. In addition, the presence of the two alleles in individuals genetically unrelated to the White New Zealand breed suggests that this polymorphism is widespread.

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