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Chromosome assignment and restriction fragment length polymorphism analysis of the anonymous DNA probe B79a at 7q22 (HMG8 assignment D7S13)

✍ Scribed by X. Estivill; J. Schmidtke; R. Williamson; B. Wainwright

Publisher: Springer
Year: 1986
Tongue: English
Weight: 237 KB
Volume: 74
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00282558

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✦ Synopsis

The anonymous DNA fragment B79a, which had previously been located to chromosome 7cen-7q22, has been more accurately assigned to 7q22 by dosage analysis in a patient hemizygous for a deletion of that region. By examination of a panel of genomic DNAs from unrelated individuals, digested with a number of different restriction enzymes, we have identified two frequent RFLPs detected by B79a. This probe will be important in the analysis of cystic fibrosis which has been mapped to the region around 7q22.