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Human DNA repair systems: An overview

✍ Scribed by Zhe Yu; Jian Chen; Barry N. Ford; Moyra E. Brackley; Barry W. Glickman

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 116 KB
Volume: 33
Category: Article
ISSN: 0893-6692
DOI: 10.1002/(sici)1098-2280(1999)33:1<3::aid-em2>3.0.co;2-l

No coin nor oath required. For personal study only.

✦ Synopsis

DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. More than 70 human genes directly involved in the five major pathways of DNA repair have been described, including chromosomal location and cDNA sequence. However, a great deal of information as to the precise functions of these genes and their role in human health is still lacking.

Hence, we summarize what is known about these genes and their contra part in bacterial, yeast, and rodent systems and discuss their involvement in human disease. While some associations are already well understood, it is clear that additional diseases will be found which are linked to DNA repair defects or deficiencies.

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