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Structure and function of the components of the human DNA mismatch repair system

✍ Scribed by Thomas Jascur; C. Richard Boland

Publisher: John Wiley and Sons
Year: 2006
Tongue: French
Weight: 347 KB
Volume: 119
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.22023

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✦ Synopsis

Abstract

DNA mismatch repair (MMR) is one of the several enzyme systems involved in DNA homeostasis. DNA MMR is involved in the repair of specific types of errors that occur during new DNA synthesis; loss of this system leads to an accelerated accumulation of potential mutations, and predisposes to certain types of cancers. Germline mutations in some of the DNA MMR genes cause the hereditary cancer predisposition, Lynch syndrome. This review addresses advances in the biochemistry of DNA MMR and its relationship to carcinogenesis. © 2006 Wiley‐Liss, Inc.

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