## Abstract Meiosis is the key process for recombination and reduction of the diploid chromosome set to a haploid one. Many genes that have been found in yeast or mouse models to play a role in meiosis are also important for the repair of DNA damage in somatic cells. To study the DNA repair gene tr
Human DNA repair genes
β Scribed by Amiram Ronen; Barry W. Glickman
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 245 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.1033
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract To determine whether variations in DNA repair genes are related to host DNA damage, we investigated the association between polymorphism in the __XPD__ gene (codon 199, 312, 751) and the __XRCC1__ gene (codon 194, 399) and the presence of benzo(a)pyrene diolepoxide adducts to lymphocyte
## Abstract Although most advanced cancers are incurable, the majority of testicular germ cell tumors can be cured using cisplatinβbased combination chemotherapy. The nucleotide excision repair (NER) pathway removes most DNA adducts produced by cisplatin, and the low levels of NER in testis tumor c
DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. More than 70 human genes directly involved in the five major pathways of DNA repair have been described, including chromosomal location and cDNA sequence.
## Abstract The human protein MED1, also known as MBD4, was isolated in a yeast twoβhybrid screening as an interactor of the mismatch repair protein MLH1. MED1 contains an Nβterminal 5βmethylcytosine binding domain (MBD), which allows binding to methylated DNA, and a Cβterminal catalytic domain wit